A new treatment for cirrhosis is being tested in clinical trials, and it could reverse the damage to the liver. It’s a strategy that has been successful in other types of disease and may help people with fatty liver avoid needing a liver transplant. This new treatment for cirrhosis will have a significant effect on transforming patient’s lives.
The liver is a vital organ that helps fight infections
The liver is a vital organ that helps fight infections, regulates blood pressure and makes red blood cells; it also stores and transports fats, vitamins and minerals in the body.
When your liver is damaged, it can’t do all those things, so it doesn’t work well. This can lead to symptoms like fatigue, loss of appetite and swelling in the abdomen and legs.
Treatment for cirrhosis typically involves medications, diet and lifestyle changes to improve your liver’s health. But some patients may develop complications like ascites, gastrointestinal bleeding and hepatic encephalopathy (HE), which can cause death in people with cirrhosis.
Currently, the best available treatment for cirrhosis is a liver transplant. However, it’s a limited resource and can’t cure all cases of the condition.
A new treatment for cirrhosis that works without harmful side effects is being tested in clinical trials. It’s called resmetirom and doctors say it could reverse the damage to the liver.
The treatment uses pristine 724, a drug that has antifibrotic properties in experimental models of liver fibrosis related to HCV infection and carbon tetrachloride toxicity. It’s being tested in a phase 3 trial, called REVERSE, with a primary endpoint of a one-stage reduction in fibrosis and a reduction in esophageal varices.
How to reverse liver cirrhosis naturally
The liver is one of the most important organs in the body. It plays a vital role in the conversion of nutrients into energy and the removal of toxins. When the liver is damaged, it can no longer work properly.
Cirrhosis (chronic liver disease) occurs when scar tissue replaces healthy tissue in the liver. This scarring can interrupt the flow of blood to liver cells, leading to poor liver functioning.
Symptoms of cirrhosis include swelling, pain, and loss of appetite. People may also have trouble concentrating and have memory problems.
Liver cancer: Hepatocellular carcinoma, a type of liver cancer, is more common in patients with cirrhosis. Regular ultrasound scans are helpful in detecting HCC.
Portal hypertension: Nodules and scar tissue in the liver can press on blood vessels, causing high pressures within these veins. This pressure can cause fluid to build up in the blood vessels of your esophagus and stomach, called varices, which can bleed and be life threatening.
Changes in your blood: Decreased white blood cells and platelets in your blood are the first signs of cirrhosis. This can be the result of changes in your liver that interfere with the production of certain proteins, which help blood cells clot.
Other spleen problems: Bleeding from enlarged varices can lead to serious bleeding. This is because the blood cannot clot correctly due to low levels of clotting factors in your liver.
Many doctors and other healthcare professionals believe that cirrhosis is irreversible, which means it can only be treated with surgery or a liver transplant. But a growing number of researchers are rethinking this belief. They think that a combination of vascular and cellular alterations could reverse the progression of liver damage in some cases.
How I cure my liver cirrhosis
About Cirrhosis
When a person has cirrhosis, healthy liver cells are replaced with scar tissue. The liver is no longer able to perform its many vital functions, such as breaking down certain drugs and alcohol and filtering toxins out of the blood. How to cure liver cirrhosis by quitting alcohol, followed the recommendation of medical experts and start living a healthy lifestyle.
The damage to the liver can occur from several causes. Common factors include excessive drinking of alcohol, hepatitis B and C virus infections, and fatty liver that’s caused by obesity and diabetes.
Cirrhosis is often treated with medications to slow the progression of the disease and to manage symptoms. The goal is to halt the progress of scar tissue, reduce the risk of complications, and prevent liver failure.
Liver Cirrhosis Symptoms
People with liver cirrhosis may have a buildup of bilirubin, which can make their skin and eyes yellow. They also have a buildup of ammonia, which can damage the nervous system and brain (hepatic encephalopathy).
Some people with liver cirrhosis develop ascites, fluid that builds up in the abdominal cavity. Ascites is a complication that needs treatment quickly.
Hepatic encephalopathy, an increase in toxins in the brain, can cause mental confusion and difficulty thinking. This condition is a serious complication and can be fatal, if not treated.
Jaundice, a yellowing of the skin and eyes, is another complication that occurs in many people with cirrhosis. This is because the liver can’t break down a buildup of bilirubin, a waste product in the blood.
Some people with cirrhosis develop bleeding varices in the esophagus or stomach, where enlarged blood vessels may burst. This can lead to black, tarry or bloody stools that need urgent medical attention.
What are the first signs of cirrhosis of the liver?
The early stage of cirrhosis is called compensated cirrhosis. In this stage, your liver has enough scar tissue to make it more difficult for it to perform its many important functions.
Your doctor diagnoses cirrhosis by asking questions about your medical history, performing a physical exam and blood, imaging, and other diagnostic tests. You may also need a liver biopsy to confirm the diagnosis or determine other causes of your liver damage or enlargement.
Bleeding
Cirrhosis can make it harder for your liver to produce clotting factors (proteins that help blood clot). So, blood clots more easily and cause internal bleeding.
Portal hypertension
Your body’s blood pressure increases as a result of cirrhosis, which raises the pressure in the vein that carries blood from your intestines and spleen to your liver (the portal vein). This condition can cause enlarged veins in your stomach or food pipe or esophagus (called varices) that are more likely to burst.
Jaundice
Yellowing of the skin and eyes is one of the first signs of cirrhosis because your liver is not able to get rid of bilirubin, a waste product from your red blood cells. It can also lead to ascites, a fluid buildup in your belly that can become infected or cause pain.
Abdominal pain
People with cirrhosis may notice a dull throbbing pain or a stabbing sensation in their right upper abdomen just under the ribs. General abdominal pain is common as the disease worsens, and your doctor may recommend medications to ease this discomfort.
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